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MMPs are thought to contribute to neuroinflammation, oxidative stress, and the disruption of bloodbrain barrier integrity, which are all implicated in PD pathophysiology (Behl et al

As fluid levels drop, blood volume decreases and the heart beats faster to keep essential organs supplied

Abbreviations CM: Citrulline malate NO: Nitric oxide ATP: Adenosine triphosphate MAS: Malate aspartate shuttle MDH: Malate dehydrogenase NIRS: Near infrared spectroscopy PFK: Phosphofructokinase TCA: Tricarboxylic acid HR: Heart rate GI: Gastrointestinal GVT: German volume training VO 2peak : Peak oxygen consumption EMG: Electromyography References Agudelo LZ, Ferreira DM, Dadvar S, Cervenka I, Ketscher L, Izadi M, Ruas JL (2019) Skeletal muscle PGC-11 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance