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The criteria for F1 require that there are no brands of pharmaceutical items that have the drug and are bioequivalent or biosimilar and which are listed on the PBS, or that there are no brands of pharmaceutical items having another listed drug in the same therapeutic group

Despite this, CYP2C and CYP2J enzymes can be detected in hepatocytes, cardiomyocytes, vascular endothelial cells, smooth muscle cells, and in some epithelial cells, autonomic ganglion cells, hepatocytes, nerve cells, and islet cells