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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Frumuzachi O., Gavrila L.I., Vodnar D.C., Rohn S., Mocan A

However, we do not fully understand why these aging hallmarks occur in the first place, and therefore there have been no proven solutions via human randomized clinical trials to improve or correct aging hallmarks in aging humans. The aging hallmarks that improved are mitochondrial dysfunction, altered intercellular communication, nutrient sensing, loss of proteostasis, genomic instability, cellular senescence and stem cell fatigue

Progress in Neuro-Psychopharmacology and Biological Psychiatry 99:109831 Baldo BA, Rose MA (2020) The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review