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Category 2 substances also have sufficient supporting information, but the FDA has identified significant safety risks

Fatty acid oxidation In diet-induced obese mice and ob/ob mice, 50 mg/kg twice daily for 28 days increased whole-body energy expenditure and fatty acid oxidation, reduced fat mass, lowered cholesterol and triglycerides, and improved insulin sensitivity without changing food intake

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Experimental and animal studies demonstrated that the downstream products of vitamin B12 metabolism are increased and oxidative stress, steatosis, and fibrosis develop in the liver in cystathionine -synthase-deficient mice (57)