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Furthermore, NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells that is essential for energy metabolism

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Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death

These results support the idea that, at least in North America, IgE response to Bla g 5.0101 may reflect genuine sensitization to cockroaches and that cross-reactivity is not relevant