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10.1002/bab.1797 22 QiaoD.ZhangZ.ZhangY.ChenQ.ChenY.TangY.et al (2021)

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

Due to the central role of glutamate in ALS, experimental therapies have been investigated and developed targeting glutamate signaling pathways or aimed at enhancing glutamate transport (EAAT2) function in order to restore glutamate homeostasis 34