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In this 12-week, randomised, double-blind, placebo-controlled, multicentre trial in 279 individuals with MS, the Cannabis extract (maximum daily delta-9-THC dose = 25 mg/day) produced highly significant reductions in muscle stiffness, muscle spasms, and pain relative to placebo together improved sleep quality that was evident at week-4 and maintained throughout the trial

A 2016 study of people with ulcerative colitis found that taking a mushroom supplement containing 14% lion's mane extract reduced symptoms and improved quality of life after three weeks [12]

10.1136/thorax.55.suppl_2.S45

SAC inhibits TGF-1induced myofibroblast differentiation, downregulates AKT/NF-B signaling, and preserves thiol homeostasis