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Secondly, these fatty acids compete with lipoxygenase, thus causing a downregulation in the synthesis of LTB4, which has a known pro-inflammatory role (46)

Endothelial cells in the BBB also express a variety of efflux transporter proteins that drain various lipophilic molecules from the brain back into the bloodstream[19]

167 Natural phenols like resveratrol have also exhibited efficacy in modulating multidrug resistance in tumor cells by reducing GSTs, for example, in doxorubicin-resistant Caco-2 cells

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