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Lifestyle changes, especially adherence to regular physical exercise and Mediterranean diet-as reflected by reduced oxidative stress of adipocytes (as measured by plasma levels of F2-isoprostanes and carbonyls of proteins)-showed positive effects (135, 136)

The effective therapeutic targeting of these inflammation networks requires a detailed understanding of the pathological contributions to metabolic deterioration

The ER stress is initiated with the dissociation of chaperone proteins such as GRP78/Bip and GRP94 with the ER stress sensor proteins (IRE1, PERK, and ATF6), which leads to UPR activation

However, further research is needed to clarify the specificity of AOPPs and their relationship with other biomarkers