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The binding of HK2 to mitochondria increases the glycolytic capacity and promotes PDAC immortalization [28]

Current therapeutic strategies targeting these age-related perturbations include senolytic compounds, nutritional interventions, physical activity protocols, and heterochronic parabiosis approaches (407)

Transgenerational consequences include increased white adipose depot weights, adipocyte hyperplasia and hypertrophy, and hepatic lipid accumulation (223, 229)

Bacteria interact with alveolar cells, such as alveolar epithelial cells and macrophages, which secrete cytokines and neutrophil chemokines and subsequently recruit additional immune cells from the pulmonary circulation to the site of infection