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Molecular docking studies indicated that many of these analogs maintain high-affinity constants and engage the binding pocket in the Munc13-4 MDH1STX7 disordered region interface (Supplementary Table 2)

However, a previous meta-analysis indicated that supplementation with CLA (in all studies containing c9, t11 and c12, t10 isomers in a 50/50 ratio) is associated with elevated serum levels of CRP