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The Ragulator complex tethers Rag GTPases to the lysosome, and when nutrients are in abundance this signal is relayed to the lysosomal Rags to induce formation of active heterodimers of GTP-loaded RagA or RagB bound to GDP-loaded RagC or RagD [40,42]

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Invest Ophthalmol Vis Sci 53(14):13371337 Quiroz-Mercado H, Boyer DS, Campochiaro PA, Heier JS, Kaiser PK, Kornfield J et al (2018) Randomized, prospective, double-masked, controlled phase 2b trial to evaluate the safety & efficacy of ALG-1001 (Luminate) in diabetic macular edema

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