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Virtual screening testing thousands of sequences rapidly identifying promising candidates for synthesis and testing

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It has been hypothesized that a reduction in deuterium levels in the sugar-phosphates in the DNA backbone preserves the stability of hydrogen bond networks, protecting against aneuploidy and strand breaks ( Exposure of cells to deuterium-hydrogen ratios that differ from the natural ratio of 1/6600 alter the expression of hundreds of cancer-related and kinase genes, reflecting the fact that deuterium levels play a significant role in metabolic policy

However, potential mechanisms by which these environmental agents contribute to the disease pathogenesis remains largely unknown