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Based on another RCT, a single dose of B12 (500 g/d) or its combination with B1(300 mg/d), B6 (80 mg/d), and B9 (2mg/d) during 12 weeks had favorable effects on the frequency of headache attacks and migraine disability (73)

These factors contribute to inconsistencies across clinical trials and complicate the interpretation of results

In addition, adequate zinc intake alongside chromium supplementation plays a significant role in mitigating chromium-induced cytotoxicity, OS, and apoptosis (99)