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AMPA receptors are also involved in synaptic plasticity, particularly in the early stages of long-term potentiation (LTP)

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For example, a single binding pocket of BD1 of BRDT accommodates both acetyl-lysines of H4K5acK12ac and H4K8acK16ac peptides in a wider hydrophobic pocket, showing much stronger affinity than binding to either mark individually [39]