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Factors contributing to the increased susceptibility of OLs to oxidative stress include the high intracellular iron content of the cells and relatively low levels of endogenous antioxidant proteins, which are lower in OPCs compared with mature OLs [14,15,23,24]

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Pts follow-up by imaging surveillance by ultrasound (or CT scan or MRI when appropriate) was divided into 4 groups a) regular FU every 6 months (RFU6), b) regular FU every year (RFU12), c) irregular FU less than annually (IFU), d) no FU