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The underlying mechanism involves the upregulation of Caspase 3, which induces apoptosis in Leydig and Sertoli cells of the human testis due to excessive ROS generated by heat stress (114, 115) ( Figure 2c )

[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Bernardini F.P., Gennai A., Izzo L., Zambelli A., Repaci E., Baldelli I., Fraternali-Orcioni G., Hartstein M.E., Santi P.L., Quarto R

In a recent prospective study on a sample of 1600 patients, MASLD was linked to cognitive deterioration, particularly in middle-aged people (van Kleef et al

deficiency impairs redox balance, increases oxidative damage, and alters T3/T4 metabolism