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In contrast, under antioxidant/low-ROS conditions (such as in certain tumor microenvironments or after treatment with BPC157 in our study), BACH1 becomes stabilized and can switch to promoting angiogenesis by directly activating target genes like VEGF

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These data indicate that, although resistant or tolerant plants present a higher frequency of upregulation of GPX genes, this induction is not a trend exclusive to them, being also observed in susceptible plants ( Figure 4A )