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343,345 PARP1-mediated post-translational modifications of PKM2, such as PARylation, enhance its nuclear localization and activity, 346 driving the expression of genes involved in PASMC proliferation, endothelial dysfunction, and inflammatory cytokine production, which are central to pulmonary vascular remodeling

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Application of topical phosphodiesterase 4 inhibitors in mild to moderate atopic dermatitis: A systematic review and meta-analysis