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The therapeutic era of peptides began in 1921 with the discovery of insulin, a breakthrough that revolutionized diabetes and helped establish biologic therapies in medicine Since then, peptide hormones like oxytocin and human growth hormone (GH) have entered clinical use, and glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide are now widely prescribed for obesity and metabolic diseaseconditions increasingly recognized for their effect on orthopaedic outcomes

These PRXs reduce not only H 2 O 2 but also alkyl hydroperoxide and peroxynitrite (Liebthal et al

BPC-157 helps restore the guts protective barrier and reduces intestinal permeability associated with leaky gut

Cell Mol Life Sci 71(18):34893506 Van Dyken P, Lacoste B (2018) Impact of metabolic syndrome on neuroinflammation and the bloodbrain barrier