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Overall, respiratory chain activity plays a key role in supporting amino acid homeostasis and cell proliferation, although the specific mechanisms vary among different organisms studied to date

Current pharmacotherapy of heart failure with reduced ejection fraction (HFrEF) includes combination therapy with angiotensin-converting enzyme inhibitors (ACEi) and -adrenergic receptor blockers (-AR blockers), a therapy also used as treatment for non-cardiac conditions

Smith et al., 2001

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