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For patients receiving vitamin K to reverse warfarin over-anticoagulation, INR should be checked: 3060 minutes post-PCC administration (if given) to confirm immediate correction 46 hours post-vitamin K administration to assess initial response, particularly in cases of major bleeding where additional interventions may be needed 1224 hours post-administration to confirm adequate correction and guide further vitamin K dosing Daily thereafter until INR stabilises within the target range, especially if warfarin is to be restarted In cases of major bleeding , ongoing clinical assessment is paramount