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However, it does not correct the underlying cystic fibrosis transmembrane conductance regulator defect, as shown by the lack of improvement in nasal transepithelial potential difference in cystic fibrosis transmembrane conductance regulator-deficient mice, indicating that epithelial ion transport remains impaired

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In summary, human trials performed before 2013 have shown that over-the-counter oral glutathione supplementation has a negligible effect on raising plasma levels in humans

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