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The etiology of these symptoms is unknown, however several illness-causing mechanisms have been hypothesized, including microbial persistence, host immune dysregulation through inflammatory or secondary autoimmune pathways, or altered neural networks, as in central sensitization

Statements Author contributions WL and CL wrote the manuscript

Animal studies have shown that P140 treatment reduces the clinical and histological severity of colitis in CD-induced mice, suggesting it may serve as a valuable therapeutic target for IBD [104]