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For platforms serious about unit economics, direct integration with 503A pharmacies (or acquiring a pharmacy license)removes the middleman entirely and can significantly improve per-prescription margins

In certain embodiments, the viscosity enhancing agents or viscosity modulating agents described herein are also utilized as the gelling agent for the gel formulations presented herein

Lyophilized (freeze-dried) peptide powder remains stable at room temperature during shipping but benefits from refrigeration for extended storage

In some embodiments, the otoprotectant is a compound of Formula (VIII): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4