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Additional metabolites such as capsiate (which activates TRPV1 to upregulate Gpx4 and inhibit ferroptosis)[21], petroselinic acid (which activates the AMPK-mTOR pathway to suppress apoptosis)[173], and Indole-3-lactic acid (which enhances epithelial stem cell function through YAP and Nrf2 activation and protects the gut-vascular barrier through AhR/Nrf2/STAT3-mediated claudin-2 downregulation)[174, 175]

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