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B12 requires special proteins and stomach acid to be adequately absorbed in the small bowel or terminal ileum, which is the last part of the small bowel before connecting to the colon

Gao X, Guo N, Xu H, Pan T, Lei H, Yan A, Mi Y, Xu L (2020) Ibuprofen induces ferroptosis of glioblastoma cells via downregulation of nuclear factor erythroid 2-related factor 2 signaling pathway