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When the nerve becomes inflamed, symptoms can include: Shooting or radiating pain down the leg Burning or electric sensations Numbness or tingling Weakness in the leg or foot Pain that worsens with sitting What is often overlooked is that irritated nerves become inflamed at a microscopic level

Consequently, the actin cytoskeleton undergoes contraction and disassembly due to aberrant disulfide cross-linking, ultimately triggering cell death ( Liu et al

AI and AI-assisted tools statement During the preparation of this manuscript, the AI tool ChatGPT (GPT-5, released 2025-08-07) was used to generate Figure 1 and the Graphical Abstract and to improve the readability and language of the manuscript

doi: 10.1007/s10787-025-01661-w 133 PatilRHirayYShindeSLangadeP