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Conflict of interest statement The authors declare no conflict of interest

In IBD management, achieving mucosal healing has emerged as a paramount therapeutic goal, strongly associated with sustained remission and improved long-term outcomes ( 3.1 Peripheral blood eosinophilia in IBD The correlation between eosinophilia in peripheral blood and disease has been recognized since very early times, for example, Machella and Hollan reported that steroid-refractory ulcerative colitis shows eosinophilia at the initial diagnosis ( 9 /L) is more prevalent in IBD than in healthy controls

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Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway