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This mechanism is primarily mediated by the expression of IL-4, which has the capacity to counteract IL-1, rather than TNF

However, as the disease progresses, uncontrolled necroptosis exacerbates mucosal inflammation and contributes to the transformation of inflammation into cancer (119)

Rudrapal M, Eltayeb WA, Rakshit G et al (2023) Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies