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Mechanisms of ADE ADE has been documented to occur through two distinct mechanisms in viral infections: by enhanced antibody-mediated virus uptake into Fc gamma receptor IIa (FcRIIa)-expressing phagocytic cells leading to increased viral infection and replication, or by excessive antibody Fc-mediated effector functions or immune complex formation causing enhanced inflammation and immunopathology (Fig

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Interestingly, expression of MmSNX1 fails to rescue the vacuolar degradation defect of VSRs caused by RNAi-mediated knockdown of AtSNX1 (Supplementary Fig