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Several metrics are used when considering the effectiveness of a given intervention, both related to the mitigation of adverse effects and in the time required to reach ketosis ( 3.4.1 Ketogenic diet formulations The classic KD is composed of a 4:1 ratio of fats to non-fat (carbohydrate and protein combined) calculated by molecular mass ( Adjustments of KD compositions have often been made to increase food choice flexibility, feasibility and palatability, such as less strict carbohydrate and protein restriction while still achieving nutritional ketosis