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Metabolic abnormalities are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to biosynthesis, energy intake, and redox needs through metabolic reprogramming to tolerate nutrient deficiency and hypoxic microenvironments

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This location has a height of 800 m.a.s.l., mean annual temperature is 27 C and mean annual rainfall is 1.100 mm

In summary, glutamine metabolism through both GLS isoforms was essential for maintaining TCA cycle metabolite levels, since inhibition with telaglenastat decreased the overall pool of all evaluated metabolites