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Hypoxia-mediated pathways can significantly influence the malignant behavior of cancer cells, with most downstream targets being dependent on HIFs

Qi F, Zhang F

In addition to markers of protein oxidative damage, 8-oxo-dG, a marker of DNA oxidative damage, was significantly elevated in both cerebellum and BA22 from the autism cases relative to controls

(2021) employed tandem mass tag proteomics (TMT) and mass spectrometry (MS) to analyze PBMC, identifying differential expression of proteins regulated by the liver X receptor-retinoid X receptor (LXR/RXR) pathway, which modulates lipid metabolism and inflammation, potentially influencing the expression of pro-inflammatory cytokine genes (Schulman, 2017)