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HER2 overexpression drives cancer cell proliferation by activating several downstream signaling pathways, including MAPK, PI3K/AKT, and more

The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

Dexamethasone signaling is required to establish the postmitotic state of adipocyte development