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Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells

After administration of PTER and RES at the same dose to male and female mice for 8 weeks, PTER reached higher concentrations in the serum and in the brain than RES ( The high lipophilicity of PTER allows it to easily cross the blood-brain barrier (Temsamani et al., 2015), resulting in greater neuroprotection than RES (Kutil et al., 2015), decreasing the levels of lipid and protein oxidation (Czpaski et al., 2012)

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