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In individuals with aspirin-induced urticaria-angioedema, a separate clinical entity with perhaps similar pathogenic mechanisms, Wong and colleagues reported the safe, rapid oral challenge desensitization to aspirin[91]

The combination of methylcobalamin (mB12) with low-dose folinic acid (LDFA) and sapropterin, a synthetic form of tetrahydrobiopterin (BH4) have been studied in open-label trials while high-dose folinic acid has been studied in a double-blind placebo controlled trial