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10.1016/j.cmet.2015.05.014 19 PitmanI.MorrisI

Additional antibody-drug conjugates are currently in development for a variety of cancer types (Anderl 2013)

Researchers have demonstrated that the palmitoylation of oncogenic NRAS mediated by ZDHHC9 is essential for its PM localization and downstream signaling activation, promoting leukemogenesis

The biological logic is that telomere shortening in dermal fibroblasts occurring over decades of UV exposure, oxidative stress, and replication is a primary driver of fibroblast functional decline and senescence-driven dermal thinning