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During the recruitment appointment and subsequent follow-up appointments at six and twelve months, the clinical status and mental health of all volunteers were evaluated, peripheral blood samples were collected, 45 plasma biomarkers (cytokines, chemokines, and growth factors) were assessed, and a comprehensive investigation was conducted using neuropsychological and ophthalmological tests, PET-CT, and magnetic resonance neuroimaging

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Adequate levels of B12 can improve mood, cognitive function, and memory

Even under ideal conditions, oral supplements typically have an absorption rate of only 50% or less