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Far more research is needed

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Given the interesting findings from mechanistic studies in mouse models, where FMO3 suppression reduced TMAO levels and atherosclerosis [32], further research in larger and more standardized human studies is needed to better understand the genetic regulation of TMAO metabolism and its role in CVD risk

To support your body while using creatine, you need to ensure you are getting enough fluids and, more importantly, enough electrolytes to help that water actually get into your cells