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Further studies would be needed to determine if Box1Box2 sequences can have relevant interactions with two JAKs simultaneously, although it was suggested that this may have been due to a crystal artifact (73)

This suggests AR agonists could be a promising, non-canonical treatment option for ER-positive breast cancer without the virilizing side effects of traditional AR therapies

Finally, GH was shown to increase the renal synthesis of the antiaging hormone Klotho in healthy subjects and patients with CKD, indicating that GH treatment may have beneficial effects on the cardiovascular system