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has been observed in fecal samples from patients with drug-resistant epilepsy (Shaikh et al., 2020)

Because SLAs modify gut immunity via shifting intestinal microbiota, and increasing IGF-1 in the liver rather than GH in the systemic blood or liver, we hypothesize that SLAs-shifted gut immunity may affect the production of hepatic IGF-1 through certain cytokines transferred from the intestinal tract to the liver