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Current preclinical and clinical data that supports the effectiveness of polyphenols in reducing the advancement of diseases, boosting cognitive abilities, and promoting overall brain health ( 2 Polyphenols pharmacological function to protect neuroinflammation and neurodegenerative diseases Neuroinflammation is a pathological process that involves the activation of glial cells and the subsequent production of pro-inflammatory cytokines, resulting in neuronal damage and impaired functionality (Figure 2) (Table 1 is a representation of the pharmacological function of polyphenols under different neurodegenerative diseases

PLoS ONE 8 , e54731 (2013)

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Because of the remote nature of the process, obtaining informed consent in DCTs may be more difficult