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Exhaled breath condensate (EBC) is collected by cooling exhaled air, enriched of aerosolized particles and volatile compounds contained in the breath

The primary downstream pathway involves JAK2 trans-phosphorylation and subsequent activation of STAT5a/b, which drives transcription of key targets including hepatic IGF-1, IGFALS, and feedback regulators CISH and SOCS2

Numerous researchers have identified the co-existence and symbiotic relationship between LAB and yeasts in fermented food such as sourdough (Sieuwerts et al., 2018), soy sauce (Feng et al., 2023), wine (Kang et al., 2024) and cheese (Melkonian et al., 2023)

In addition, we will discuss recent alternative PHD or FIH targets in terms of translational and physiological relevance and highlight the different techniques applied during the detection, screening and functional verification of PHD and FIH targets, see Table 1