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Glutamate receptor-mediated analgesic activity of NAC was first observed in rodent models [74,75] and this same metabotropic glutamate receptor-mediated analgesic effect of NAC was later demonstrated in human volunteers exposed to laser stimuli pain [76]

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Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, Lafaille JJ, Hempstead BL, Littman DR, Gan WB (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor