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Hyperhomocysteinemia is observed in approximately 5% of the general population and is associated with increased risk for many inflammatory disorders including auto immune disorders (Rheumatoid Arthritis, Diabetes, Multiple Sclerosis, Systemic Lupus erythematosus, Grave disease), birth defects and adverse pregnancy outcomes (pre-eclampsia, placental abruption, spontaneous abortion, low birth weight), vascular and neurodegenerative diseases

Similarly, glucose deficiency suppressed ferroptosis by inhibiting glycolysis, the TCA cycle, and fatty acid synthesis mediated via pyruvate dehydrogenase kinase 4 (PDK4) 89

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Li Q, Wang C, Mou Z