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While early studies suggest potential therapeutic effects of antioxidants in certain conditions, many of these studies are limited by small sample sizes, raising concerns about the reliability and reproducibility of the findings

ex vivo ), the muscle preparation (isolated or intact), the primary fiber type utilized, and other factors (Figure 2)

Therefore, blocking the HMGB1-AGER pathway with small molecules or genetic methods could limit the inflammatory response mediated by ferroptosis ( Radiotherapy Radiotherapy can directly cause oxidative damage to lipid membrane, leading to the accumulation of toxic lipid peroxidation and triggering ferroptosis in cancer cells

Some patients benefit from switching to a low-dose maintenance plan rather than stopping abruptly