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Downregulation of miR-200b depressed the transcription factor endothelial transcription factor GATA binding protein 2 (GATA2) and vascular endothelial growth factor receptor 2 (VEGFR2) (Li et al., 2013), decreased collagen type ratio, dysregulated expression of skin neuropeptides (Nowak et al., 2021), lack of thrombin activated fibrinolytic inhibitor (Nass et al., 2010), decreased number of epidermal nerves ( Angiopoietin-like factor 4 (ANGPTL4) is a stromal cell protein that plays an important role in lipid and glucose metabolism and promotes keratinocyte migration, proliferation and angiogenesis

Dosage is adjusted according to the patients response and the appearance of adverse reactions

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