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Description

DM refers to a group of metabolic diseases characterized by reduced insulin synthesis and release, leading to hyperglycemia, oxidative stress, and inflammation [15]

The liver tumor microenvironment (TME) consists of different cell populations including cancer cells, infiltrating immune cells, endothelial cells and cancer associated fibroblasts (CAFs)

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When the connectivity scores were close to 1, the drugs were deemed to have strong potential to restore the normal gene expression profile of the PD-associated genes