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Neuropharmacology (2019) 148:1318

The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of A oligomers through Tau phosphorylation

doi: 10.1038/s41419-022-04974-8 291 HeRLiuBXiongRGengBMengHLinWet al

It is indicated by the data of this study, that auranofin interacts with thioredoxin-glutathione reductase through a selenocysteine mediated transfer of gold from auranofin to Cys sites and gold provides the inhibitory activity, essentially making auranofin the pro-drug for gold delivery ( Leishmania infantum , offers insight into auranofin interference of the redox system by inhibiting trypanothione reductase, an enzyme that replaces many of the thioredoxin/TrxR and glutathione/glutathione reductase functions